Highly goes slowly
نویسندگان
چکیده
منابع مشابه
Highly goes slowly
Highly goes slowly ates of protein evolution vary widely. Very little of this variation is explained by dispensability (essential proteins evolving slowly), but up to a third is explained by expression levels. For an entirely mysterious reason, highly expressed proteins evolve slowly. argue that this correlation is based on the severe selective pressure on highly expressed proteins to avoid mis...
متن کاملWhy highly expressed proteins evolve slowly.
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that have remained unexplained. Here, we hypothesize that selection to reduce the burden of protein misfolding will favor protein sequences with increased robustness to translational missense errors. Pressu...
متن کاملHighly expressed genes in yeast evolve slowly.
tion of these findings is that proteins expressed in many The dataset used in this article consists of the remtissues interact with a greater number of molecules and nants of the ancient genome duplication including 376 may also have to function under widely changing cellugene pairs organized into 55 gene clusters (Wolfe and lar conditions. Hence, high pleiotropic constraints on Shields 1997). ...
متن کاملHighly nonlinear dynamics in a slowly sedimenting colloidal gel.
We use a combination of original light scattering techniques and particles with unique optical properties to investigate the behavior of suspensions of attractive colloids under gravitational stress, following over time the concentration profile, the velocity profile, and the microscopic dynamics. During the compression regime, the sedimentation velocity grows nearly linearly with height, imply...
متن کاملProtein misinteraction avoidance causes highly expressed proteins to evolve slowly.
The tempo and mode of protein evolution have been central questions in biology. Genomic data have shown a strong influence of the expression level of a protein on its rate of sequence evolution (E-R anticorrelation), which is currently explained by the protein misfolding avoidance hypothesis. Here, we show that this hypothesis does not fully explain the E-R anticorrelation, especially for prote...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1711rr1